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Epicutis Hydrobiome Serum

$165.00
  • Microbiome-balancing serum that calms redness and irritation
  • Strengthens the skin barrier while supporting clearer skin
  • Lightweight formula for sensitive skin

1.7 fl oz / 50 mL

Pickup available at YSS Del Prado

Usually ready in 24 hours


Authorized Retailer. 100% Authentic Guarantee.

Arrives end of March!

Fast Fulfillment: Orders Ship Within 24 Hours (Mon–Fri) | Orders Placed After 2 PM Friday Ship the Next Business Day

Alternative Payment Methods - Available at Checkout

  • Strengthens Barrier

    Repairs & protects skin barrier

  • Balances Microbiome

    Supports beneficial skin flora

  • Calm & Soothe

    Reduces redness and irritation

  • Microbiome Support

    Balances and restores skin

Details

Epicutis Hydrobiome Serum: Restore Balance for Calm, Resilient Skin

Epicutis Hydrobiome Serum is a lightweight, medical-grade treatment designed to calm inflammation, rebalance the skin microbiome, and strengthen the skin barrier for healthier, more resilient skin. Created using Epicutis’s biotechnology-driven approach to skincare, this advanced serum targets the biological signals that trigger redness, irritation, and breakouts.

At the heart of the formula is TCP, a patented anti-inflammatory modulator that helps regulate microbial signaling pathways linked to skin stress and blemishes. This technology works alongside TPNa, a water-soluble Vitamin E that delivers powerful antioxidant protection while helping reinforce the skin barrier. Together, these ingredients support a balanced microbiome and a calmer complexion.

The result is skin that feels hydrated, soothed, and visibly more balanced. The lightweight texture absorbs quickly, making it ideal for sensitive, reactive, or compromised skin types that require gentle yet effective support.

Why You'll Like It

  • Targets microbiome imbalance to support healthier skin
  • Helps calm visible redness and irritation
  • Strengthens the skin barrier for improved resilience
  • Provides lightweight hydration without heaviness
  • Uses biotechnology-driven ingredients for long-term skin health

Who Is It For

  • Sensitive or reactive skin
  • Redness-prone complexions
  • Skin experiencing breakouts linked to inflammation
  • Compromised or weakened skin barriers
  • Anyone seeking microbiome-supporting skincare

Epicutis Hydrobiome Serum delivers targeted microbiome support and calming hydration to help skin maintain balance, resilience, and visible comfort.

Benefits
  • Balances the skin microbiome
  • Calms inflammation and irritation
  • Strengthens and protects the skin barrier
  • Helps reduce visible redness
  • Helps kill C-Acne bacteria
  • Supports clearer-looking skin by targeting microbial imbalance
  • Provides lightweight hydration
  • Improves overall skin resilience

Epicutis Hydrobiome Serum helps restore harmony to stressed skin, supporting a calm, balanced complexion that looks healthier over time.

Epicutis Hydrobiome Serum is part of the Epicutis skincare collection, a biotechnology-driven line designed to calm inflammation, strengthen the skin barrier, and support long-term skin health. For enhanced results, many patients layer Hydrobiome Serum with Epicutis Lipid Serum, creating a comprehensive system that supports both microbiome balance and broad anti-inflammatory protection.

How to Use
  • Step 1: Apply HydroBiome Serum to clean skin to support microbiome balance and microbial signaling regulation.
  • Step 2: Follow with Lipid Serum to provide broad anti-inflammatory protection and antioxidant support.
  • Step 3: Finish with the remainder of your Epicutis routine.
    This layering approach allows each serum to support different biological drivers of skin stress, helping maintain calm, balanced, resilient skin.

With consistent use, Epicutis Hydrobiome Serum helps maintain calm, balanced skin while strengthening your skin’s natural defense system.

Ingredients

Key Ingredients

  • TCP (Disodium Tetramethylhexadecenylcysteine Formylprolinate): A patented anti-inflammatory modulator that helps regulate microbial signaling pathways associated with redness, irritation, and blemishes.
  • TPNa (Sodium Tocopheryl Phosphate): A water-soluble form of Vitamin E that provides antioxidant protection while helping strengthen the skin barrier.
  • Sodium Hyaluronate: A form of hyaluronic acid that attracts and retains moisture, helping maintain skin hydration and suppleness.
  • Glycerin: A powerful humectant that helps draw moisture into the skin for improved hydration and comfort.
  • Protease and Lipase: Enzymes that support the skin’s natural renewal processes and contribute to overall skin balance.

Full Ingredients: Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide, Protease, Lipase.

Ingredients may change. Please check the packaging for the most current list.

Epicutis Hydrobiome Serum combines biotechnology and carefully selected ingredients to support a balanced microbiome and healthier skin over time.

FAQ

What does Epicutis Hydrobiome Serum do?
Epicutis Hydrobiome Serum helps rebalance the skin microbiome while calming inflammation, strengthening the skin barrier, and reducing visible redness.

How does the technology in Epicutis Hydrobiome Serum work?
Epicutis Hydrobiome Serum works by supporting the skin’s microbiome, the community of beneficial microorganisms that help keep skin healthy and balanced. The formula helps calm inflammatory signals while strengthening the skin barrier, allowing skin to maintain hydration and resilience. By supporting microbiome balance and reducing skin stress, the serum helps improve the appearance of redness, sensitivity, and breakouts over time.

Is Epicutis Hydrobiome Serum suitable for sensitive skin?
Yes. The formula was designed for sensitive and reactive skin types, providing calming hydration and microbiome support without irritation.

Can Hydrobiome Serum help with breakouts?
Yes. By helping regulate microbial signaling pathways, the serum supports a balanced microbiome that can contribute to clearer-looking skin.

Can I use Hydrobiome Serum with Lipid Serum?
Yes. These serums support different inflammatory pathways. Hydrobiome Serum should be applied first, followed by Lipid Serum for comprehensive skin support.

Is Epicutis Hydrobiome Serum safe for daily use?
Yes. The lightweight formula is designed for daily use and can be applied morning and night as part of your skincare routine.

If your skin struggles with redness, sensitivity, or stress, Epicutis Hydrobiome Serum provides targeted support that helps restore balance while reinforcing your skin’s natural defenses.

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Genuine, Authorized Epicutis Products

We are proud to be an Authorized Epicutis Retailer, offering the same professional products that are sold and used in our medical spa. Every Epicutis product you purchase from Your Skincare Source is 100% authentic, brand-new, and packaged by the manufacturer to ensure quality, safety, and freshness.

All orders are stored and shipped from our environmentally controlled facility in Cape Coral, Florida, helping preserve product integrity, quality, and efficacy. 

Shop with confidence knowing your products are genuine, carefully handled, and professionally trusted.

Frequently Asked Questions

Shipping

How much does shipping cost?

Free Shipping

Free standard shipping is available on domestic orders that meet the minimum product total shown in the site banner ($75). Shipping fees are not included in the qualifying amount.

Shipping Rates

  • USPS Ground Advantage - $10
  • UPS - Calculated at Checkout

Shipping Extras

  • Signature Confirmation available for $3.00

Do you ship on the same day?

Fast Shipping

We ship Monday to Friday from our spa in Florida.

Same Day Shipping Deadlines

  • Monday to Friday - Orders ship within 24 hrs
  • After 2 pm Friday - Ships next business day
  • Saturday, Sunday, Holidays - No Shipping

What countries do you ship to?

We currently ship to the United States.

Details

Epicutis Hydrobiome Serum: Restore Balance for Calm, Resilient Skin

Epicutis Hydrobiome Serum is a lightweight, medical-grade treatment designed to calm inflammation, rebalance the skin microbiome, and strengthen the skin barrier for healthier, more resilient skin. Created using Epicutis’s biotechnology-driven approach to skincare, this advanced serum targets the biological signals that trigger redness, irritation, and breakouts.

At the heart of the formula is TCP, a patented anti-inflammatory modulator that helps regulate microbial signaling pathways linked to skin stress and blemishes. This technology works alongside TPNa, a water-soluble Vitamin E that delivers powerful antioxidant protection while helping reinforce the skin barrier. Together, these ingredients support a balanced microbiome and a calmer complexion.

The result is skin that feels hydrated, soothed, and visibly more balanced. The lightweight texture absorbs quickly, making it ideal for sensitive, reactive, or compromised skin types that require gentle yet effective support.

Why You'll Like It

  • Targets microbiome imbalance to support healthier skin
  • Helps calm visible redness and irritation
  • Strengthens the skin barrier for improved resilience
  • Provides lightweight hydration without heaviness
  • Uses biotechnology-driven ingredients for long-term skin health

Who Is It For

  • Sensitive or reactive skin
  • Redness-prone complexions
  • Skin experiencing breakouts linked to inflammation
  • Compromised or weakened skin barriers
  • Anyone seeking microbiome-supporting skincare

Epicutis Hydrobiome Serum delivers targeted microbiome support and calming hydration to help skin maintain balance, resilience, and visible comfort.

Benefits
  • Balances the skin microbiome
  • Calms inflammation and irritation
  • Strengthens and protects the skin barrier
  • Helps reduce visible redness
  • Helps kill C-Acne bacteria
  • Supports clearer-looking skin by targeting microbial imbalance
  • Provides lightweight hydration
  • Improves overall skin resilience

Epicutis Hydrobiome Serum helps restore harmony to stressed skin, supporting a calm, balanced complexion that looks healthier over time.

Epicutis Hydrobiome Serum is part of the Epicutis skincare collection, a biotechnology-driven line designed to calm inflammation, strengthen the skin barrier, and support long-term skin health. For enhanced results, many patients layer Hydrobiome Serum with Epicutis Lipid Serum, creating a comprehensive system that supports both microbiome balance and broad anti-inflammatory protection.

How to Use
  • Step 1: Apply HydroBiome Serum to clean skin to support microbiome balance and microbial signaling regulation.
  • Step 2: Follow with Lipid Serum to provide broad anti-inflammatory protection and antioxidant support.
  • Step 3: Finish with the remainder of your Epicutis routine.
    This layering approach allows each serum to support different biological drivers of skin stress, helping maintain calm, balanced, resilient skin.

With consistent use, Epicutis Hydrobiome Serum helps maintain calm, balanced skin while strengthening your skin’s natural defense system.

Ingredients

Key Ingredients

  • TCP (Disodium Tetramethylhexadecenylcysteine Formylprolinate): A patented anti-inflammatory modulator that helps regulate microbial signaling pathways associated with redness, irritation, and blemishes.
  • TPNa (Sodium Tocopheryl Phosphate): A water-soluble form of Vitamin E that provides antioxidant protection while helping strengthen the skin barrier.
  • Sodium Hyaluronate: A form of hyaluronic acid that attracts and retains moisture, helping maintain skin hydration and suppleness.
  • Glycerin: A powerful humectant that helps draw moisture into the skin for improved hydration and comfort.
  • Protease and Lipase: Enzymes that support the skin’s natural renewal processes and contribute to overall skin balance.

Full Ingredients: Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide, Protease, Lipase.

Ingredients may change. Please check the packaging for the most current list.

Epicutis Hydrobiome Serum combines biotechnology and carefully selected ingredients to support a balanced microbiome and healthier skin over time.

FAQ

What does Epicutis Hydrobiome Serum do?
Epicutis Hydrobiome Serum helps rebalance the skin microbiome while calming inflammation, strengthening the skin barrier, and reducing visible redness.

How does the technology in Epicutis Hydrobiome Serum work?
Epicutis Hydrobiome Serum works by supporting the skin’s microbiome, the community of beneficial microorganisms that help keep skin healthy and balanced. The formula helps calm inflammatory signals while strengthening the skin barrier, allowing skin to maintain hydration and resilience. By supporting microbiome balance and reducing skin stress, the serum helps improve the appearance of redness, sensitivity, and breakouts over time.

Is Epicutis Hydrobiome Serum suitable for sensitive skin?
Yes. The formula was designed for sensitive and reactive skin types, providing calming hydration and microbiome support without irritation.

Can Hydrobiome Serum help with breakouts?
Yes. By helping regulate microbial signaling pathways, the serum supports a balanced microbiome that can contribute to clearer-looking skin.

Can I use Hydrobiome Serum with Lipid Serum?
Yes. These serums support different inflammatory pathways. Hydrobiome Serum should be applied first, followed by Lipid Serum for comprehensive skin support.

Is Epicutis Hydrobiome Serum safe for daily use?
Yes. The lightweight formula is designed for daily use and can be applied morning and night as part of your skincare routine.

If your skin struggles with redness, sensitivity, or stress, Epicutis Hydrobiome Serum provides targeted support that helps restore balance while reinforcing your skin’s natural defenses.