SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator
- Instant and long-term hydration
- Boost Hyaluronic Acid production
- Helps fine lines and wrinkles
SkinMedica HA5 Hydra Collagen Replenish + Restore Hydrator is backordered and will ship as soon as it is back in stock.
2 fl oz
Couldn't load pickup availability
Earn [points_amount] when you buy this item.
Same Day, Next Day Shipping - Mon-Fri
-
HA Complex
Boosts hydration & HA
-
Instant Hydration
Long-term too!
-
Plumps & Refreshes
Leaves skin soft and dewy
-
Strengthens Barrier
Repairs & protects skin barrier

- Details
- Benefits
- How to Use
- Ingredients
- FAQ
HA5 Hydra Collagen: Advanced Hydration and Collagen Support
Experience a next-level hydrator that visibly plumps and restores your skin. SkinMedica HA5 Hydra Collagen Replenish & Restore Hydrator blends five forms of hyaluronic acid with collagen-supporting peptides for all-day moisture and improved skin elasticity.
An evolution in hydration: Meet the next generation of HA⁵® with twice the hyaluronic acid. Now boosted with Hydra Collagen for instant moisture and silky softness, plus Advanced Vitiscence Technology to replenish natural humectants, including HA, and help restore your skin’s hydration reservoir.
Delivers immediate moisture that lasts up to 48 hours for plumper, dewier, and healthier-looking skin with fewer visible lines.
Clinical Highlights:
- Instantly smooths the look of fine lines and rough texture.
- Improves skin firmness and bounce with continued use.
- Boosts natural collagen production for long-term radiance.
- In a clinical study, patients reported they looked ~ 3 years younger by week 12 (Date on file at SkinMedica)
Why You’ll Love It:
Lightweight yet powerful, this formula quenches thirsty skin and helps maintain a supple, youthful glow.
Who It’s For
Ideal for all skin types seeking deep hydration, especially those concerned with early signs of aging or loss of firmness.
Exponentially Smooth
HA5 supports the skin’s ability to replenish its own hyaluronic acid (HA) for overall skin health. HA5 has a proprietary mix of five HA forms that smooth the skin, thereby decreasing the appearance of fine lines and wrinkles. The 5 HA’s work synergistically to provide immediate smoothing and continuous hydration throughout the day.
See for yourself how HA5 Hydra Collagen can replenish and restore your skin daily for a softer, plumper, and more radiant look.
- Deep, multi-level hydration with five HA forms
- Enhances collagen for improved elasticity
- Reduces fine lines and wrinkles
- Strengthens the skin barrier against moisture loss
Enjoy round-the-clock hydration and visible firmness with every application.
- Dispense 1 to 2 pumps into your palm and smooth onto the skin. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
- Apply morning and evening to clean, dry skin.
- Smooth a small amount over the face, neck, décolletage, or any area that needs hydration.
- Follow with your favorite moisturizer or sunscreen.
SkinMedica Recommended HA5 Protocol:
- Cleanse with HA⁵ Hydra Collagen Hydrating Foaming Cleanser
- Hydrate with HA⁵ Hydra Collagen Replenish and Restore Hydrator
- Moisturize with HA⁵ Hydra Collagen Water Burst Moisturizer
Consistency is key, use daily for optimal hydration and collagen support.
Key Ingredients
VITISENSCE® Technology - A SkinMedica exclusive technology that harnesses potent antioxidants found in Vitis Flower Stem Cell Extract, Peptide Complex to support rejuvenation and hydration, and Polysaccharides from French Polynesia for healthy-looking skin, all working to support skin’s ability to replenish its own hyaluronic acid for overall skin health.
Proprietary HA⁵ Hydra Collagen Complex
Hydration Collagen - vegan collagen that attracts and retains water for instant hydration and smoothness
5 Forms of Hyaluronic Acid:
A proprietary mix of 5 types of HA that smooths the skin, thereby decreasing the appearance of fine lines and wrinkles.
- Vectorized Time Release HA - A SkinMedica® proprietary ingredient for sustained release of HA
- Cross-linked HA - Provides long-lasting hydration
- Liposomally Encapsulated HA - For immediate hydration
- Noncross-linked HA - For smoothness and hydration
- Nano-hyaluronic acid - Soothes skin
- Contains vegan collagen.
Full Ingredients: Aqua/Water/Eau, Glycerin, Caprylic/Capric Triglyceride, Shorea Stenoptera Seed Butter, C9-12 Alkane, Propanediol, Linoleic Acid, Sodium Acrylates Copolymer, Passiflora Edulis Seed Oil, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Nelumbo Nucifera Germ Extract, Vegan Biomimetic Collagen, Butyl Avocadate, Trehalose, Serine, Vitis Vinifera (Grape) Flower Cell Extract, Linolenic Acid, Urea, Caprylhydroxamic Acid, Algin, Polyglutamic Acid, Tocopherol, Oleic Acid, Pullulan, Palmitic Acid, Glyceryl Glucoside, Coco-Caprylate/Caprate, Lecithin, 1,2-Hexanediol, Pentylene Glycol, Stearic Acid, Benzoic Acid, Caprylyl Glycol, Polysorbate 20, Dehydroacetic Acid, Glyceryl Polyacrylate, Potassium Phosphate, Benzyl Alcohol, Disodium Phosphate, Sodium Benzoate.
Ingredients may change. Please check the packaging for the most current list.
What makes HA5 Hydra Collagen unique?
It combines five molecular weights of hyaluronic acid with collagen-supporting peptides for deeper, longer-lasting hydration and firmness.
Can it be used with other serums or retinoids?
Yes, apply after cleansing and before serums or treatments for optimal layering. SkinMedica recommends applying HA5 after TNS Advanced + Serum.
Is it suitable for oily or sensitive skin?
Absolutely. The lightweight texture absorbs quickly without greasiness and is gentle for sensitive types.
When will I see results?
You’ll notice immediate hydration and smoother texture. Collagen-support benefits appear with consistent use over 4–6 weeks.
Do I need extra moisturizer afterward?
Many users find it hydrating enough alone, but you can layer a moisturizer if your skin is very dry.
What is the SkinMedica Hydration Collection and how effective is it?
The Hydration Collection pairs HA5 Hydra Collagen Hydrating Foaming Cleanser with HA5 Hydra Collagen Replenish + Restore Hydrator for an immediate 30% boost in hydration. In a clinical study:
- Twice as many people reported a dewy, hydrated glow after using the cleanser alone.
- Four times as many reported a dewy, hydrated glow when using the cleanser and hydrator together.
- After a single use, 92% agreed their skin looked and felt hydrated, smooth, and nourished.
- Based on a clinical study of 26 participants. Data on file at SkinMedica.
For all-day extra moisture and skin barrier care, pair it with HA5 Hydra Collagen Water Burst Moisturizer.
Trust SkinMedica science to keep your skin hydrated, firm, and radiant.
Let everyone know how much you loved this product...
Leave a Review...
Leave your honest review on the products you purchased at Your Skincare Source!
You will earn 50 points for each approved review.
Frequently Asked Questions
Shipping
How much does shipping cost?
How much does shipping cost?
Free Shipping
Free standard shipping is available on domestic orders that meet the minimum product total shown in the site banner ($75). Shipping fees are not included in the qualifying amount.
Shipping Rates
- USPS Ground Advantage - $10
- UPS - Calculated at Checkout
Shipping Extras
- Signature Confirmation available for $3.00
Do you ship on the same day?
Do you ship on the same day?
Fast Shipping
We ship Monday to Friday, from our spa in Florida.
Same Day Shipping Deadlines
- Monday to Friday - Order by 2 pm PST
- Saturday, Sunday, Holidays - No Shipping
What countries do you ship to?
What countries do you ship to?
We currently ship to the United States.