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SkinMedica Barrier Calming Cream

$140.00
  • Clinically proven support for retinol-treated skin
  • 40% reduction in dryness after 6 weeks with retinol
  • Restorative, noncomedogenic barrier moisturizer for all skin types

1.7 fl oz / 50 mL

Pickup available at YSS Del Prado

Usually ready in 24 hours


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Fast Fulfillment: Orders Ship Within 24 Hours (Mon–Fri) | Orders Placed After 2 PM Friday Ship the Next Business Day

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  • Strengthens Barrier

    Repairs & protects skin barrier

  • Calming

    Soothes redness & irritation

  • Deep Hydration

    Nourishing & restoring

  • Calm & Soothe

    Reduces redness and irritation

Details

SkinMedica Barrier Calming Cream: Clinically Proven Barrier Support

SkinMedica Barrier Calming Cream is a restorative, noncomedogenic moisturizer designed to soothe, hydrate, and fortify the skin barrier while helping optimize skin renewal. Clinically proven to support skin's tolerance to retinol, this rich yet skin-comforting cream helps improve hydration and visible redness while replenishing moisture that can be compromised by active skincare routines.

Designed for all skin types, Barrier Calming Cream is especially beneficial when skin feels dry, sensitized, irritated, or visibly red. Its formula combines glycerin, niacinamide, skin-supportive lipids, panthenol, bisabolol, and a blend of botanical ingredients to help restore comfort while supporting a healthier, more resilient skin barrier.

In a SkinMedica study of patients using Retinol Complex 0.5, 100% agreed that Barrier Calming Cream reduced irritation and replenished their skin barrier. The regimen also demonstrated a 40% reduction in dryness after six weeks.1

Why You'll Like It

  • Clinically proven to support skin's tolerance to retinol by improving hydration and visible redness
  • Helps replenish and strengthen the skin's moisture barrier
  • Helps soothe irritation associated with retinol use
  • Provides restorative hydration for dry or sensitized skin
  • Noncomedogenic formula suitable for all skin types
  • Complements active skincare routines without sacrificing skin comfort

Who Is It For

  • All skin types
  • Skin experiencing dryness, sensitivity, or visible redness
  • Retinol users who need additional hydration and barrier support
  • Anyone looking to strengthen a stressed or compromised skin barrier
  • Skincare routines focused on renewal while maintaining skin comfort

SkinMedica Barrier Calming Cream makes it easier to support visible skin renewal while giving the barrier the hydration and calming care it needs.

Benefits
  • Clinically proven to help improve hydration and visible redness during retinol use
  • Helps support improved skin tolerance to retinol
  • Helps replenish and fortify the skin barrier
  • Provides restorative hydration for dry and sensitized skin
  • Helps soothe visible signs of irritation
  • Supports a calmer, more comfortable-looking complexion
  • Noncomedogenic formula designed for all skin types
  • Helps support skin renewal while maintaining barrier comfort

In a SkinMedica study, 100% of patients agreed Barrier Calming Cream reduced irritation and replenished their skin barrier when used with Retinol Complex 0.5, with a 40% reduction in dryness after six weeks. (Data on file at SkinMedica®.)

For anyone balancing visible renewal with skin comfort, Barrier Calming Cream provides clinically supported hydration and barrier care.

This product is part of the SkinMedica skincare collection, a science-driven professional skincare line combining advanced formulations with targeted solutions for healthier, more resilient-looking skin.

How to Use
  • Apply twice daily after cleansing, toning, and applying treatment products.
  • Apply one pump over the entire face, extending to the neck and décolleté if desired.
  • Gently massage into the skin until absorbed.

Use consistently to help maintain hydration, skin comfort, and barrier support, particularly when incorporating retinol into your routine.

Ingredients

Key Ingredients:

  • Niacinamide: A versatile form of vitamin B3 that helps support the skin barrier, improve moisture retention, and promote a calmer, more balanced-looking complexion.
  • Glycerin: A proven humectant that attracts and holds moisture to help keep skin hydrated, soft, and comfortable.
  • Barrier-Supportive Lipids: Phospholipids, glycosphingolipids, glycolipids, sphingolipids, and lecithin-based ingredients help support the lipid-rich structure of the skin's protective barrier.
  • Panthenol and Bisabolol: Skin-conditioning ingredients that help support hydration and comfort, particularly when skin feels dry or sensitized.
  • Botanical Extract Blend: Oat kernel, cucumber, tomato, rose, Ophiopogon japonicus, willow bark, and coriander-derived ingredients complement the formula with soothing, conditioning, and antioxidant-supportive properties.
  • Vitamin C and Vitamin E Derivatives: Ascorbyl palmitate, tocopherol, and tocopheryl acetate provide antioxidant support within the formula.
  • Collagen: Helps condition the skin and contributes to the moisturizing, smoothing feel of the formula.

Full Ingredients: Aqua/Water/Eau, Isononyl Isononanoate, Glycerin, Niacinamide, C15-19 Alkane, C13-15 Alkane, Phosphatidylcholine, Arachidyl Alcohol, Polyacrylate Crosspolymer-6, Myristyl Myristate, Coriandrum Sativum (Coriander) Seed Oil, Collagen, Stearyl Glycyrrhetinate, Ophiopogon Japonicus Root Extract, Rosa Chinensis Flower Extract, Solanum Lycopersicum (Tomato) Fruit Extract, Salix Alba (Willow) Bark Extract, Avena Sativa (Oat) Kernel Extract, Cucumis Sativus (Cucumber) Fruit Extract, p-Anisic Acid, Ascorbyl Palmitate, Tocopheryl Acetate, Retinyl Palmitate, Tocopherol, Panthenol, Bisabolol, Glyceryl Glucoside, Glycosphingolipids, Hydrogenated Lecithin, Glycolipids, Arachidyl Glucoside, 1,2-Hexanediol, Ethyl Lauroyl Arginate HCl, Sphingolipids, Phospholipids, Pentylene Glycol, Maltodextrin, Propylene Glycol, Polyquaternium-51, t-Butyl Alcohol, Acacia Senegal Gum, Behenyl Alcohol, Caprylyl Glycol, Silica, Calcium Chloride, Xanthan Gum, Sodium Citrate, Potassium Sorbate, Citric Acid

Ingredients may change. Please check the packaging for the most current list.

By combining humectants, lipids, niacinamide, antioxidants, and soothing ingredients, SkinMedica Barrier Calming Cream takes a comprehensive formulation approach to moisture and barrier support.

FAQ

What does SkinMedica Barrier Calming Cream do?

SkinMedica Barrier Calming Cream is designed to moisturize dry or sensitized skin while helping support the skin's protective barrier. Its combination of glycerin, niacinamide, skin-supportive lipids, panthenol, bisabolol, and botanical ingredients also helps promote a calmer and more comfortable-looking complexion.

Who should use SkinMedica Barrier Calming Cream?

It is especially appropriate for normal-to-dry skin and skin experiencing dryness, visible redness, sensitivity, or barrier stress. Its richer moisturizing profile also makes it a good choice when a lightweight moisturizer is not providing enough comfort or moisture.

Is SkinMedica Barrier Calming Cream suitable for sensitive skin?

SkinMedica positions Barrier Calming Cream for all skin types, and its restorative formula is specifically designed to help soothe and fortify the delicate skin barrier. It can be particularly helpful when skin becomes dry, visibly red, or irritated from an active skincare routine.

Can SkinMedica Barrier Calming Cream be used with retinol?

Yes, it can be applied as the moisturizing step after treatment products such as retinoids. A barrier-supportive moisturizer can be especially useful when an active skincare routine leaves skin feeling dry or uncomfortable. Introduce stronger treatments gradually and adjust their frequency if irritation becomes persistent.

Can SkinMedica Barrier Calming Cream help with retinol irritation?

Yes. SkinMedica Barrier Calming Cream is clinically proven to support skin's tolerance to retinol by improving hydration and visible redness. In a SkinMedica study of 14 patients using Retinol Complex 0.5, 100% agreed that Barrier Calming Cream reduced irritation and replenished their skin barrier, and dryness was reduced by 40% after six weeks. Data on file at SkinMedica.

Is SkinMedica Barrier Calming Cream noncomedogenic?

Yes. SkinMedica identifies Barrier Calming Cream as noncomedogenic. This makes it a useful moisturizing option for shoppers who want restorative barrier support without using a formula designed to clog pores.

When should SkinMedica Barrier Calming Cream be applied?

Apply it after cleansing, toning, and treatment serums, typically morning and evening. In a daytime routine, moisturizer should be followed by an appropriate broad-spectrum sunscreen.

Can I use SkinMedica Barrier Calming Cream with SkinMedica HA5 Hydra Collagen Hydrator?

Yes. For a hydration-focused routine, apply SkinMedica HA5 Hydra Collagen Hydrator with Vegan Collagen before Barrier Calming Cream. The hydrator provides a lightweight moisture-focused treatment layer, while Barrier Calming Cream can follow as the richer moisturizing and barrier-supportive step.

What is the difference between hydration and skin barrier support?

Hydration focuses on increasing and maintaining water within the skin, while barrier support focuses on helping the outer protective layer retain moisture and remain resilient. SkinMedica Barrier Calming Cream addresses both needs by combining humectants such as glycerin with niacinamide and multiple lipid-based ingredients.

Can SkinMedica Barrier Calming Cream be used morning and night?

Yes. Current use directions recommend applying the cream twice daily after treatment products. Using it consistently morning and evening helps maintain a more stable level of moisture and barrier support.

SkinMedica Barrier Calming Cream is a strong choice when the goal is not simply to moisturize, but to give dry, stressed, or sensitized skin more comprehensive daily support.

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Genuine, Authorized SkinMedica Products

We are proud to be an Authorized SkinMedica Retailer, offering the same professional products that are sold and used in our medical spa. Every SkinMedica product you purchase from Your Skincare Source is 100% authentic, brand-new, and packaged by the manufacturer to ensure quality, safety, and freshness.

All orders are stored and shipped from our environmentally controlled facility in Cape Coral, Florida, helping preserve product integrity, quality, and efficacy. 

Shop with confidence knowing your products are genuine, carefully handled, and professionally trusted.

Shipping Frequently Asked Questions

Shipping

How much does shipping cost?

Free Shipping

Free standard shipping is available on domestic orders that meet the minimum product total shown in the site banner ($50). Shipping fees are not included in the qualifying amount.

Shipping Rates

  • USPS Ground Advantage - $10
  • UPS - Calculated at Checkout

Shipping Extras

  • Signature Confirmation available for $3.00

Do you ship on the same day?

Fast Shipping

We ship Monday to Friday from our spa in Florida.

Same Day Shipping Deadlines

  • Monday to Friday - Orders ship within 24 hrs
  • After 2 pm Friday - Ships next business day
  • Saturday, Sunday, Holidays - No Shipping

What countries do you ship to?

We currently ship to the United States.

Details

SkinMedica Barrier Calming Cream: Clinically Proven Barrier Support

SkinMedica Barrier Calming Cream is a restorative, noncomedogenic moisturizer designed to soothe, hydrate, and fortify the skin barrier while helping optimize skin renewal. Clinically proven to support skin's tolerance to retinol, this rich yet skin-comforting cream helps improve hydration and visible redness while replenishing moisture that can be compromised by active skincare routines.

Designed for all skin types, Barrier Calming Cream is especially beneficial when skin feels dry, sensitized, irritated, or visibly red. Its formula combines glycerin, niacinamide, skin-supportive lipids, panthenol, bisabolol, and a blend of botanical ingredients to help restore comfort while supporting a healthier, more resilient skin barrier.

In a SkinMedica study of patients using Retinol Complex 0.5, 100% agreed that Barrier Calming Cream reduced irritation and replenished their skin barrier. The regimen also demonstrated a 40% reduction in dryness after six weeks.1

Why You'll Like It

  • Clinically proven to support skin's tolerance to retinol by improving hydration and visible redness
  • Helps replenish and strengthen the skin's moisture barrier
  • Helps soothe irritation associated with retinol use
  • Provides restorative hydration for dry or sensitized skin
  • Noncomedogenic formula suitable for all skin types
  • Complements active skincare routines without sacrificing skin comfort

Who Is It For

  • All skin types
  • Skin experiencing dryness, sensitivity, or visible redness
  • Retinol users who need additional hydration and barrier support
  • Anyone looking to strengthen a stressed or compromised skin barrier
  • Skincare routines focused on renewal while maintaining skin comfort

SkinMedica Barrier Calming Cream makes it easier to support visible skin renewal while giving the barrier the hydration and calming care it needs.

Benefits
  • Clinically proven to help improve hydration and visible redness during retinol use
  • Helps support improved skin tolerance to retinol
  • Helps replenish and fortify the skin barrier
  • Provides restorative hydration for dry and sensitized skin
  • Helps soothe visible signs of irritation
  • Supports a calmer, more comfortable-looking complexion
  • Noncomedogenic formula designed for all skin types
  • Helps support skin renewal while maintaining barrier comfort

In a SkinMedica study, 100% of patients agreed Barrier Calming Cream reduced irritation and replenished their skin barrier when used with Retinol Complex 0.5, with a 40% reduction in dryness after six weeks. (Data on file at SkinMedica®.)

For anyone balancing visible renewal with skin comfort, Barrier Calming Cream provides clinically supported hydration and barrier care.

This product is part of the SkinMedica skincare collection, a science-driven professional skincare line combining advanced formulations with targeted solutions for healthier, more resilient-looking skin.

How to Use
  • Apply twice daily after cleansing, toning, and applying treatment products.
  • Apply one pump over the entire face, extending to the neck and décolleté if desired.
  • Gently massage into the skin until absorbed.

Use consistently to help maintain hydration, skin comfort, and barrier support, particularly when incorporating retinol into your routine.

Ingredients

Key Ingredients:

  • Niacinamide: A versatile form of vitamin B3 that helps support the skin barrier, improve moisture retention, and promote a calmer, more balanced-looking complexion.
  • Glycerin: A proven humectant that attracts and holds moisture to help keep skin hydrated, soft, and comfortable.
  • Barrier-Supportive Lipids: Phospholipids, glycosphingolipids, glycolipids, sphingolipids, and lecithin-based ingredients help support the lipid-rich structure of the skin's protective barrier.
  • Panthenol and Bisabolol: Skin-conditioning ingredients that help support hydration and comfort, particularly when skin feels dry or sensitized.
  • Botanical Extract Blend: Oat kernel, cucumber, tomato, rose, Ophiopogon japonicus, willow bark, and coriander-derived ingredients complement the formula with soothing, conditioning, and antioxidant-supportive properties.
  • Vitamin C and Vitamin E Derivatives: Ascorbyl palmitate, tocopherol, and tocopheryl acetate provide antioxidant support within the formula.
  • Collagen: Helps condition the skin and contributes to the moisturizing, smoothing feel of the formula.

Full Ingredients: Aqua/Water/Eau, Isononyl Isononanoate, Glycerin, Niacinamide, C15-19 Alkane, C13-15 Alkane, Phosphatidylcholine, Arachidyl Alcohol, Polyacrylate Crosspolymer-6, Myristyl Myristate, Coriandrum Sativum (Coriander) Seed Oil, Collagen, Stearyl Glycyrrhetinate, Ophiopogon Japonicus Root Extract, Rosa Chinensis Flower Extract, Solanum Lycopersicum (Tomato) Fruit Extract, Salix Alba (Willow) Bark Extract, Avena Sativa (Oat) Kernel Extract, Cucumis Sativus (Cucumber) Fruit Extract, p-Anisic Acid, Ascorbyl Palmitate, Tocopheryl Acetate, Retinyl Palmitate, Tocopherol, Panthenol, Bisabolol, Glyceryl Glucoside, Glycosphingolipids, Hydrogenated Lecithin, Glycolipids, Arachidyl Glucoside, 1,2-Hexanediol, Ethyl Lauroyl Arginate HCl, Sphingolipids, Phospholipids, Pentylene Glycol, Maltodextrin, Propylene Glycol, Polyquaternium-51, t-Butyl Alcohol, Acacia Senegal Gum, Behenyl Alcohol, Caprylyl Glycol, Silica, Calcium Chloride, Xanthan Gum, Sodium Citrate, Potassium Sorbate, Citric Acid

Ingredients may change. Please check the packaging for the most current list.

By combining humectants, lipids, niacinamide, antioxidants, and soothing ingredients, SkinMedica Barrier Calming Cream takes a comprehensive formulation approach to moisture and barrier support.

FAQ

What does SkinMedica Barrier Calming Cream do?

SkinMedica Barrier Calming Cream is designed to moisturize dry or sensitized skin while helping support the skin's protective barrier. Its combination of glycerin, niacinamide, skin-supportive lipids, panthenol, bisabolol, and botanical ingredients also helps promote a calmer and more comfortable-looking complexion.

Who should use SkinMedica Barrier Calming Cream?

It is especially appropriate for normal-to-dry skin and skin experiencing dryness, visible redness, sensitivity, or barrier stress. Its richer moisturizing profile also makes it a good choice when a lightweight moisturizer is not providing enough comfort or moisture.

Is SkinMedica Barrier Calming Cream suitable for sensitive skin?

SkinMedica positions Barrier Calming Cream for all skin types, and its restorative formula is specifically designed to help soothe and fortify the delicate skin barrier. It can be particularly helpful when skin becomes dry, visibly red, or irritated from an active skincare routine.

Can SkinMedica Barrier Calming Cream be used with retinol?

Yes, it can be applied as the moisturizing step after treatment products such as retinoids. A barrier-supportive moisturizer can be especially useful when an active skincare routine leaves skin feeling dry or uncomfortable. Introduce stronger treatments gradually and adjust their frequency if irritation becomes persistent.

Can SkinMedica Barrier Calming Cream help with retinol irritation?

Yes. SkinMedica Barrier Calming Cream is clinically proven to support skin's tolerance to retinol by improving hydration and visible redness. In a SkinMedica study of 14 patients using Retinol Complex 0.5, 100% agreed that Barrier Calming Cream reduced irritation and replenished their skin barrier, and dryness was reduced by 40% after six weeks. Data on file at SkinMedica.

Is SkinMedica Barrier Calming Cream noncomedogenic?

Yes. SkinMedica identifies Barrier Calming Cream as noncomedogenic. This makes it a useful moisturizing option for shoppers who want restorative barrier support without using a formula designed to clog pores.

When should SkinMedica Barrier Calming Cream be applied?

Apply it after cleansing, toning, and treatment serums, typically morning and evening. In a daytime routine, moisturizer should be followed by an appropriate broad-spectrum sunscreen.

Can I use SkinMedica Barrier Calming Cream with SkinMedica HA5 Hydra Collagen Hydrator?

Yes. For a hydration-focused routine, apply SkinMedica HA5 Hydra Collagen Hydrator with Vegan Collagen before Barrier Calming Cream. The hydrator provides a lightweight moisture-focused treatment layer, while Barrier Calming Cream can follow as the richer moisturizing and barrier-supportive step.

What is the difference between hydration and skin barrier support?

Hydration focuses on increasing and maintaining water within the skin, while barrier support focuses on helping the outer protective layer retain moisture and remain resilient. SkinMedica Barrier Calming Cream addresses both needs by combining humectants such as glycerin with niacinamide and multiple lipid-based ingredients.

Can SkinMedica Barrier Calming Cream be used morning and night?

Yes. Current use directions recommend applying the cream twice daily after treatment products. Using it consistently morning and evening helps maintain a more stable level of moisture and barrier support.

SkinMedica Barrier Calming Cream is a strong choice when the goal is not simply to moisturize, but to give dry, stressed, or sensitized skin more comprehensive daily support.